A Conserved Salt Bridge between Transmembrane Segments 1 and 10 Constitutes an Extracellular Gate in the Dopamine Transporter

Por Pedersen, Anders V., Andreassen, Thorvald F., Loland, Claus J.
Publicado no J Biol Chem (2014)

A Rhodamine-Labeled Citalopram Analogue as a High-Affinity Fluorescent Probe for the Serotonin Transporter

Por Zhang, Peng, Jørgensen, Trine Nygaard, Loland, Claus J., Newman, Amy Hauck
Publicado em 2012

Neuropsychiatric disease–associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

Por Herborg, Freja, Andreassen, Thorvald F., Berlin, Frida, Loland, Claus J., Gether, Ulrik
Publicado no J Biol Chem (2018)

An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter

Por Kniazeff, Julie, Shi, Lei, Loland, Claus J., Javitch, Jonathan A., Weinstein, Harel, Gether, Ulrik
Publicado em 2008

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na(+) and K(+) Ions and the Protonation State of Glu(290)

Por Khelashvili, George, Schmidt, Solveig Gaarde, Shi, Lei, Javitch, Jonathan A., Gether, Ulrik, Loland, Claus J., Weinstein, Harel
Publicado no J Biol Chem (2016)

Surface Targeting of the Dopamine Transporter Involves Discrete Epitopes in the Distal C Terminus But Does Not Require Canonical PDZ Domain Interactions

Por Bjerggaard, Christian, Fog, Jacob U., Hastrup, Hanne, Madsen, Kenneth, Loland, Claus J., Javitch, Jonathan A., Gether, Ulrik
Publicado no J Neurosci (2004)

Steric Hindrance Mutagenesis in the Conserved Extracellular Vestibule Impedes Allosteric Binding of Antidepressants to the Serotonin Transporter

Por Plenge, Per, Shi, Lei, Beuming, Thijs, Te, Jerez, Newman, Amy Hauck, Weinstein, Harel, Gether, Ulrik, Loland, Claus J.
Publicado em 2012

Elucidation of Structural Elements for Selectivity across Monoamine Transporters: Novel 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues

Por Okunola-Bakare, Oluyomi M., Cao, Jianjing, Kopajtic, Theresa, Katz, Jonathan L., Loland, Claus J., Shi, Lei, Newman, Amy Hauck
Publicado em 2014

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT

Por Merkle, Patrick S., Gotfryd, Kamil, Cuendet, Michel A., Leth-Espensen, Katrine Z., Gether, Ulrik, Loland, Claus J., Rand, Kasper D.
Publicado no Sci Adv (2018)

Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter

Por Billesbølle, Christian B., Mortensen, Jonas S., Sohail, Azmat, Schmidt, Solveig G., Shi, Lei, Sitte, Harald H., Gether, Ulrik, Loland, Claus J.
Publicado no Nat Commun (2016)

Conformational dynamics of the human serotonin transporter during substrate and drug binding

Por Möller, Ingvar R., Slivacka, Marika, Nielsen, Anne Kathrine, Rasmussen, Søren G. F., Gether, Ulrik, Loland, Claus J., Rand, Kasper D.
Publicado no Nat Commun (2019)

Substrate-induced conformational dynamics of the dopamine transporter

Por Nielsen, Anne Kathrine, Möller, Ingvar R., Wang, Yong, Rasmussen, Søren G. F., Lindorff-Larsen, Kresten, Rand, Kasper D., Loland, Claus J.
Publicado no Nat Commun (2019)

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

Por Plenge, Per, Abramyan, Ara M., Sørensen, Gunnar, Mørk, Arne, Weikop, Pia, Gether, Ulrik, Bang-Andersen, Benny, Shi, Lei, Loland, Claus J.
Publicado no Nat Commun (2020)

The binding sites for benztropines and dopamine in the dopamine transporter overlap

Por Bisgaard, Heidi, Larsen, M. Andreas B., Mazier, Sonia, Beuming, Thijs, Newman, Amy Hauck, Weinstein, Harel, Shi, Lei, Loland, Claus J., Gether, Ulrik
Publicado em 2010

A class of rigid linker-bearing glucosides for membrane protein structural study

Por Sadaf, Aiman, Mortensen, Jonas S., Capaldi, Stefano, Tikhonova, Elena, Hariharan, Parameswaran, Ribeiro, Orquidea, Loland, Claus J., Guan, Lan, Byrne, Bernadette, Chae, Pil Seok
Publicado no Chem Sci (2016)

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation()

Por Bae, Hyoung Eun, Mortensen, Jonas S., Ribeiro, Orquidea, Du, Yang, Ehsan, Muhammad, Kobilka, Brian K., Loland, Claus J., Byrne, Bernadette, Chae, Pil Seok
Publicado no Chem Commun (Camb) (2016)

Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region

Por Das, Manabendra, Du, Yang, Mortensen, Jonas S., Ribeiro, Orquidea, Hariharan, Parameswaran, Guan, Lan, Loland, Claus J., Kobilka, Brian K., Byrne, Bernadette, Chae, Pil Seok
Publicado no Chem Sci (2017)

Mechanism of the Association between Na(+) Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters

Por Stolzenberg, Sebastian, Quick, Matthias, Zhao, Chunfeng, Gotfryd, Kamil, Khelashvili, George, Gether, Ulrik, Loland, Claus J., Javitch, Jonathan A., Noskov, Sergei, Weinstein, Harel, Shi, Lei
Publicado no J Biol Chem (2015)

Rationally engineered tandem facial amphiphiles for improved membrane protein stabilization efficacy

Por Das, Manabendra, Du, Yang, Mortensen, Jonas S., Hariharan, Parameswaran, Lee, Hyun Sung, Byrne, Bernadette, Loland, Claus J., Guan, Lan, Kobilka, Brian K., Chae, Pil Seok
Publicado no Chembiochem (2018)

Novel Xylene-linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation

Por Cho, Kyung Ho, Du, Yang, Scull, Nicola J, Hariharan, Parameswaran, Gotfryd, Kamil, Loland, Claus J, Guan, Lan, Byrne, Bernadette, Kobilka, Brian K, Chae, Pil Seok
Publicado no Chemistry (2015)