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Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT
LeuT, a prokaryotic member of the neurotransmitter:sodium symporter (NSS) family, is an established structural model for mammalian NSS counterparts. We investigate the substrate translocation mechanism of LeuT by measuring the solution-phase structural dynamics of the transporter in distinct functio...
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| Опубликовано в: : | Sci Adv |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Association for the Advancement of Science
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5947982/ https://ncbi.nlm.nih.gov/pubmed/29756037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aar6179 |
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