X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Neurotransmitter:sodium symporters (NSS) are conserved from bacteria to man and serve as targets for drugs, including antidepressants and psychostimulants. Here we report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na(+)/substrate-bound, inward-facing occluded conformation. To obta...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gotfryd, Kamil, Boesen, Thomas, Mortensen, Jonas S., Khelashvili, George, Quick, Matthias, Terry, Daniel S., Missel, Julie W., LeVine, Michael V., Gourdon, Pontus, Blanchard, Scott C., Javitch, Jonathan A., Weinstein, Harel, Loland, Claus J., Nissen, Poul, Gether, Ulrik
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035281/
https://ncbi.nlm.nih.gov/pubmed/32081981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14735-w
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