A partially-open inward-facing intermediate conformation of LeuT is associated with Na(+) release and substrate transport

Neurotransmitter:sodium symporters (NSS), targets of antidepressants and psychostimulants, clear neurotransmitters from the synaptic cleft through sodium (Na(+))-coupled transport. Substrate and Na(+) are thought to be transported from the extracellular to intracellular space through an alternating...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Terry, Daniel S., Kolster, Rachel A., Quick, Matthias, LeVine, Michael V., Khelashvili, George, Zhou, Zhou, Weinstein, Harel, Javitch, Jonathan A., Blanchard, Scott C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768729/
https://ncbi.nlm.nih.gov/pubmed/29335402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02202-y
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