Conformational dynamics of ligand-dependent alternating access in LeuT

The leucine transporter (LeuT) from Aquifex aeolicus is a bacterial homolog of neurotransmitter:sodium symporters (NSS) that catalyze reuptake of neurotransmitters at the synapse. Crystal structures of wild type (WT) and mutants of LeuT have been interpreted as conformational states in the coupled t...

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Main Authors: Kazmier, Kelli, Sharma, Shruti, Quick, Matthias, Islam, Shahidul M., Roux, Benoit, Weinstein, Harel, Javitch, Jonathan A., Mchaourab, Hassane S.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050370/
https://ncbi.nlm.nih.gov/pubmed/24747939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2816
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