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Experimental conditions can obscure the second high-affinity site in LeuT
Neurotransmitter:Na(+) Symporters (NSSs), the targets of antidepressants and psychostimulants, recapture neurotransmitters from the synapse in a Na(+)-dependent symport mechanism. The crystal structure of the NSS homologue LeuT from Aquifex aeolicus revealed one leucine substrate in an occluded cent...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272158/ https://ncbi.nlm.nih.gov/pubmed/22245968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2197 |
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