Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

The first crystal structure of the neurotransmitter/sodium symporter homolog LeuT revealed an occluded binding pocket containing leucine and 2 Na(+); later structures showed tricyclic antidepressants (TCAs) in an extracellular vestibule ≈11 Å above the bound leucine and 2 Na(+). We recently found th...

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Detaylı Bibliyografya
Asıl Yazarlar: Quick, Matthias, Winther, Anne-Marie Lund, Shi, Lei, Nissen, Poul, Weinstein, Harel, Javitch, Jonathan A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667088/
https://ncbi.nlm.nih.gov/pubmed/19307590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811322106
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