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Conformational cycle and ion-coupling mechanism of the Na(+)/hydantoin transporter Mhp1

Ion-dependent transporters of the LeuT-fold couple the uptake of physiologically essential molecules to transmembrane ion gradients. Defined by a conserved 5-helix inverted repeat that encodes common principles of ion and substrate binding, the LeuT-fold has been captured in outward-facing, occluded...

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Autors principals: Kazmier, Kelli, Sharma, Shruti, Islam, Shahidul M., Roux, Benoît, Mchaourab, Hassane S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4205665/
https://ncbi.nlm.nih.gov/pubmed/25267652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410431111
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