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Alternating access mechanisms of LeuT-Fold transporters: trailblazing towards the promised energy landscapes
Secondary active transporters couple the uphill translocation of substrates to electrochemical ion gradients. Transporter conformational motion, generically referred to as alternating access, enables a central ligand binding site to change its orientation relative to the membrane. Here we review the...
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| Veröffentlicht in: | Curr Opin Struct Biol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5491374/ https://ncbi.nlm.nih.gov/pubmed/28040635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2016.12.006 |
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