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X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
Neurotransmitter:sodium symporters (NSS) are conserved from bacteria to man and serve as targets for drugs, including antidepressants and psychostimulants. Here we report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na(+)/substrate-bound, inward-facing occluded conformation. To obta...
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| Izdano u: | Nat Commun |
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| Glavni autori: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7035281/ https://ncbi.nlm.nih.gov/pubmed/32081981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14735-w |
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