X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Neurotransmitter:sodium symporters (NSS) are conserved from bacteria to man and serve as targets for drugs, including antidepressants and psychostimulants. Here we report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na(+)/substrate-bound, inward-facing occluded conformation. To obta...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Gotfryd, Kamil, Boesen, Thomas, Mortensen, Jonas S., Khelashvili, George, Quick, Matthias, Terry, Daniel S., Missel, Julie W., LeVine, Michael V., Gourdon, Pontus, Blanchard, Scott C., Javitch, Jonathan A., Weinstein, Harel, Loland, Claus J., Nissen, Poul, Gether, Ulrik
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035281/
https://ncbi.nlm.nih.gov/pubmed/32081981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14735-w
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