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Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na(+) and K(+) Ions and the Protonation State of Glu(290)
Ions play key mechanistic roles in the gating dynamics of neurotransmitter:sodium symporters (NSSs). In recent microsecond scale molecular dynamics simulations of a complete model of the dopamine transporter, a NSS protein, we observed a partitioning of K(+) ions from the intracellular side toward t...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5025669/ https://ncbi.nlm.nih.gov/pubmed/27474737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731455 |
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