Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na(+) and K(+) Ions and the Protonation State of Glu(290)

Ions play key mechanistic roles in the gating dynamics of neurotransmitter:sodium symporters (NSSs). In recent microsecond scale molecular dynamics simulations of a complete model of the dopamine transporter, a NSS protein, we observed a partitioning of K(+) ions from the intracellular side toward t...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Khelashvili, George, Schmidt, Solveig Gaarde, Shi, Lei, Javitch, Jonathan A., Gether, Ulrik, Loland, Claus J., Weinstein, Harel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Molecular Biophysics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025669/
https://ncbi.nlm.nih.gov/pubmed/27474737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.731455
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