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The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
The serotonin transporter (SERT) terminates serotonin signaling by rapid presynaptic reuptake. SERT activity is modulated by antidepressants, e.g., S-citalopram and imipramine, to alleviate symptoms of depression and anxiety. SERT crystal structures reveal two S-citalopram binding pockets in the cen...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7083837/ https://ncbi.nlm.nih.gov/pubmed/32198394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15292-y |
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