Structure–activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5‐HT transporter

BACKGROUND AND PURPOSE: The 5‐HT transporter (SERT) is a target for antidepressant drugs. SERT possesses two binding sites: the orthosteric (S1) binding site, which is the presumed target for current SERT inhibitors, and an allosteric (S2) site for which potential therapeutic effects are unknown. Th...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Larsen, M Andreas B, Plenge, Per, Andersen, Jacob, Eildal, Jonas NN, Kristensen, Anders S, Bøgesø, Klaus P, Gether, Ulrik, Strømgaard, Kristian, Bang‐Andersen, Benny, Loland, Claus J
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761100/
https://ncbi.nlm.nih.gov/pubmed/26699847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13411
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