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Mutational Mapping and Modeling of the Binding Site for (S)-Citalopram in the Human Serotonin Transporter
The serotonin transporter (SERT) regulates extracellular levels of the neurotransmitter serotonin (5-hydroxytryptamine) in the brain by facilitating uptake of released 5-hydroxytryptamine into neuronal cells. SERT is the target for widely used antidepressant drugs, including imipramine, fluoxetine,...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2804362/ https://ncbi.nlm.nih.gov/pubmed/19892699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072587 |
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