Mutational Mapping and Modeling of the Binding Site for (S)-Citalopram in the Human Serotonin Transporter

The serotonin transporter (SERT) regulates extracellular levels of the neurotransmitter serotonin (5-hydroxytryptamine) in the brain by facilitating uptake of released 5-hydroxytryptamine into neuronal cells. SERT is the target for widely used antidepressant drugs, including imipramine, fluoxetine,...

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Bibliografiska uppgifter
Huvudupphovsmän: Andersen, Jacob, Olsen, Lars, Hansen, Kasper B., Taboureau, Olivier, Jørgensen, Flemming S., Jørgensen, Anne Marie, Bang-Andersen, Benny, Egebjerg, Jan, Strømgaard, Kristian, Kristensen, Anders S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2010
Ämnen:
Membrane Transport, Structure, Function, and Biogenesis
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2804362/
https://ncbi.nlm.nih.gov/pubmed/19892699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072587
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