Thiazide effects and side effects: insights from molecular genetics

Por Ellison, David H., Loffing, Johannes
Publicado em 2009

The Mouse Isolated Perfused Kidney Technique

Por Czogalla, Jan, Schweda, Frank, Loffing, Johannes
Publicado no J Vis Exp (2016)

Akt Substrate of 160 kD Regulates Na(+),K(+)-ATPase Trafficking in Response to Energy Depletion and Renal Ischemia

Por Alves, Daiane S., Thulin, Gunilla, Loffing, Johannes, Kashgarian, Michael, Caplan, Michael J.
Publicado no J Am Soc Nephrol (2015)

Endothelin‐1 mediates natriuresis but not polyuria during vitamin D‐induced acute hypercalcaemia

Por Tokonami, Natsuko, Cheval, Lydie, Monnay, Isabelle, Meurice, Guillaume, Loffing, Johannes, Feraille, Eric, Houillier, Pascal
Publicado no J Physiol (2017)

Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3

Por Ishizawa, Kenichi, Xu, Ning, Loffing, Johannes, Lifton, Richard P., Fujita, Toshiro, Uchida, Shunya, Shibata, Shigeru
Publicado no Biochem Biophys Res Commun (2016)

Defective regulation of the epithelial Na(+) channel by Nedd4 in Liddle's syndrome

Por Abriel, Hugues, Loffing, Johannes, Rebhun, John F., Pratt, J. Howard, Schild, Laurent, Horisberger, Jean-Daniel, Rotin, Daniela, Staub, Olivier
Publicado em 1999

αENaC-Mediated Lithium Absorption Promotes Nephrogenic Diabetes Insipidus

Por Christensen, Birgitte Mønster, Zuber, Annie Mercier, Loffing, Johannes, Stehle, Jean-Christophe, Deen, Peter M.T., Rossier, Bernard C., Hummler, Edith
Publicado em 2011

Enhanced passive Ca(2+) reabsorption and reduced Mg(2+) channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia

Por Nijenhuis, Tom, Vallon, Volker, van der Kemp, Annemiete W.C.M., Loffing, Johannes, Hoenderop, Joost G.J., Bindels, René J.M.
Publicado em 2005

Protein Phosphatase 1 Inhibitor-1 Deficiency Reduces Phosphorylation of Renal NaCl Cotransporter and Causes Arterial Hypotension

Por Picard, Nicolas, Trompf, Katja, Yang, Chao-Ling, Miller, R. Lance, Carrel, Monique, Loffing-Cueni, Dominique, Fenton, Robert A., Ellison, David H., Loffing, Johannes
Publicado em 2014

Mechanisms of Renal Control of Potassium Homeostasis in Complete Aldosterone Deficiency

Por Todkar, Abhijeet, Picard, Nicolas, Loffing-Cueni, Dominique, Sorensen, Mads V., Mihailova, Marija, Nesterov, Viatcheslav, Makhanova, Natalia, Korbmacher, Christoph, Wagner, Carsten A., Loffing, Johannes
Publicado no J Am Soc Nephrol (2015)

Collecting duct–specific gene inactivation of αENaC in the mouse kidney does not impair sodium and potassium balance

Por Rubera, Isabelle, Loffing, Johannes, Palmer, Lawrence G., Frindt, Gustavo, Fowler-Jaeger, Nicole, Sauter, Daniel, Carroll, Tom, McMahon, Andrew, Hummler, Edith, Rossier, Bernard C.
Publicado em 2003

Acetazolamide Attenuates Lithium–Induced Nephrogenic Diabetes Insipidus

Por de Groot, Theun, Sinke, Anne P., Kortenoeven, Marleen L.A., Alsady, Mohammad, Baumgarten, Ruben, Devuyst, Olivier, Loffing, Johannes, Wetzels, Jack F., Deen, Peter M.T.
Publicado no J Am Soc Nephrol (2016)

Extracellular K(+) rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl(−)‐dependent and independent mechanisms

Por Penton, David, Czogalla, Jan, Wengi, Agnieszka, Himmerkus, Nina, Loffing‐Cueni, Dominique, Carrel, Monique, Rajaram, Renuga Devi, Staub, Olivier, Bleich, Markus, Schweda, Frank, Loffing, Johannes
Publicado no J Physiol (2016)

Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension

Por Hadchouel, Juliette, Soukaseum, Christelle, Büsst, Cara, Zhou, Xiao-ou, Baudrie, Véronique, Zürrer, Tany, Cambillau, Michelle, Elghozi, Jean-Luc, Lifton, Richard P., Loffing, Johannes, Jeunemaitre, Xavier
Publicado em 2010

Renal tubular SGK1 deficiency causes impaired K(+) excretion via loss of regulation of NEDD4-2/WNK1 and ENaC

Por Al-Qusairi, Lama, Basquin, Denis, Roy, Ankita, Stifanelli, Matteo, Rajaram, Renuga Devi, Debonneville, Anne, Nita, Izabela, Maillard, Marc, Loffing, Johannes, Subramanya, Arohan R., Staub, Olivier
Publicado no Am J Physiol Renal Physiol (2016)

Renal expression of parvalbumin is critical for NaCl handling and response to diuretics

Por Belge, Hendrica, Gailly, Philippe, Schwaller, Beat, Loffing, Johannes, Debaix, Huguette, Riveira-Munoz, Eva, Beauwens, Renaud, Devogelaer, Jean-Pierre, Hoenderop, Joost G., Bindels, René J., Devuyst, Olivier
Publicado em 2007

SYMPATHETIC STIMULATION OF THIAZIDE-SENSITIVE SODIUM-CHLORIDE COTRANSPORT IN THE GENERATION OF SALT-SENSITIVE HYPERTENSION

Por Terker, Andrew S., Yang, Chao-Ling, McCormick, James A., Meermeier, Nicholas P., Rogers, Shaunessy L., Grossmann, Solveig, Trompf, Katja, Delpire, Eric, Loffing, Johannes, Ellison, David H.
Publicado em 2014

Severe Salt–Losing Syndrome and Hyperkalemia Induced by Adult Nephron–Specific Knockout of the Epithelial Sodium Channel α-Subunit

Por Perrier, Romain, Boscardin, Emilie, Malsure, Sumedha, Sergi, Chloé, Maillard, Marc P., Loffing, Johannes, Loffing-Cueni, Dominique, Sørensen, Mads Vaarby, Koesters, Robert, Rossier, Bernard C., Frateschi, Simona, Hummler, Edith
Publicado no J Am Soc Nephrol (2016)

Impaired renal Na(+) retention in the sgk1-knockout mouse

Por Wulff, Peer, Vallon, Volker, Huang, Dan Yang, Völkl, Harald, Yu, Fang, Richter, Kerstin, Jansen, Martina, Schlünz, Michaela, Klingel, Karin, Loffing, Johannes, Kauselmann, Gunther, Bösl, Michael R., Lang, Florian, Kuhl, Dietmar
Publicado em 2002

Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression

Por Debonneville, Christophe, Flores, Sandra Y., Kamynina, Elena, Plant, Pamela J., Tauxe, Caroline, Thomas, Marc A., Münster, Carole, Chraïbi, Ahmed, Pratt, J.Howard, Horisberger, Jean-Daniel, Pearce, David, Loffing, Johannes, Staub, Olivier
Publicado em 2001