Extracellular K(+) rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl(−)‐dependent and independent mechanisms

KEY POINTS: High dietary potassium (K(+)) intake dephosphorylates and inactivates the NaCl cotransporter (NCC) in the renal distal convoluted tubule (DCT). Using several ex vivo models, we show that physiological changes in extracellular K(+), similar to those occurring after a K(+) rich diet, are s...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Penton, David, Czogalla, Jan, Wengi, Agnieszka, Himmerkus, Nina, Loffing‐Cueni, Dominique, Carrel, Monique, Rajaram, Renuga Devi, Staub, Olivier, Bleich, Markus, Schweda, Frank, Loffing, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Renal and endocrine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088235/
https://ncbi.nlm.nih.gov/pubmed/27457700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272504
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