Protein Phosphatase 1 Inhibitor-1 Deficiency Reduces Phosphorylation of Renal NaCl Cotransporter and Causes Arterial Hypotension

The thiazide-sensitive NaCl cotransporter (NCC) of the renal distal convoluted tubule (DCT) controls ion homeostasis and arterial BP. Loss-of-function mutations of NCC cause renal salt wasting with arterial hypotension (Gitelman syndrome). Conversely, mutations in the NCC-regulating WNK kinases or k...

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Detalhes bibliográficos
Main Authors: Picard, Nicolas, Trompf, Katja, Yang, Chao-Ling, Miller, R. Lance, Carrel, Monique, Loffing-Cueni, Dominique, Fenton, Robert A., Ellison, David H., Loffing, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2014
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935578/
https://ncbi.nlm.nih.gov/pubmed/24231659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012121202
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