Enhanced passive Ca(2+) reabsorption and reduced Mg(2+) channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia

Thiazide diuretics enhance renal Na(+) excretion by blocking the Na(+)-Cl(–) cotransporter (NCC), and mutations in NCC result in Gitelman syndrome. The mechanisms underlying the accompanying hypocalciuria and hypomagnesemia remain debated. Here, we show that enhanced passive Ca(2+) transport in the...

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Main Authors: Nijenhuis, Tom, Vallon, Volker, van der Kemp, Annemiete W.C.M., Loffing, Johannes, Hoenderop, Joost G.J., Bindels, René J.M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2005
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1090474/
https://ncbi.nlm.nih.gov/pubmed/15902302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI24134
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