Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension

Mutations in WNK1 and WNK4 lead to familial hyperkalemic hypertension (FHHt). Because FHHt associates net positive Na(+) balance together with K(+) and H(+) renal retention, the identification of WNK1 and WNK4 led to a new paradigm to explain how aldosterone can promote either Na(+) reabsorption or...

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Detalhes bibliográficos
Main Authors: Hadchouel, Juliette, Soukaseum, Christelle, Büsst, Cara, Zhou, Xiao-ou, Baudrie, Véronique, Zürrer, Tany, Cambillau, Michelle, Elghozi, Jean-Luc, Lifton, Richard P., Loffing, Johannes, Jeunemaitre, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964238/
https://ncbi.nlm.nih.gov/pubmed/20921400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006128107
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