Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4

Mutations of the gene encoding WNK1 [With No lysine (K) kinase 1] or WNK4 cause Familial Hyperkalemic Hypertension (FHHt). Previous studies have shown that the activation of SPAK (Ste20-related Proline/Alanine-rich Kinase) plays a dominant role in the development of FHHt caused by WNK4 mutations. Th...

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Vydáno v:Sci Rep
Hlavní autoři: Rafael, Chloé, Soukaseum, Christelle, Baudrie, Véronique, Frère, Perrine, Hadchouel, Juliette
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818654/
https://ncbi.nlm.nih.gov/pubmed/29459793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21405-x
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