WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron

Large deletions in the first intron of the With No lysine (K) 1 (WNK1) gene are responsible for Familial Hyperkalemic Hypertension (FHHt), a rare form of human hypertension associated with hyperkalemia and hyperchloremic metabolic acidosis. We generated a mouse model of WNK1-associated FHHt to explo...

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Autori principali: Vidal-Petiot, Emmanuelle, Elvira-Matelot, Emilie, Mutig, Kerim, Soukaseum, Christelle, Baudrie, Véronique, Wu, Shengnan, Cheval, Lydie, Huc, Elizabeth, Cambillau, Michèle, Bachmann, Sebastian, Doucet, Alain, Jeunemaitre, Xavier, Hadchouel, Juliette
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761585/
https://ncbi.nlm.nih.gov/pubmed/23940364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304230110
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