The WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the NaCl cotransporter via SPAK, an effect antagonized by WNK4

The With No lysine kinases WNK1 and WNK4 are key regulators of blood pressure. Their mutations lead to Familial Hyperkalemic Hypertension (FHHt), associated with an activation of the Na-Cl cotransporter, NCC. Although it is clear that WNK4 mutants activate NCC via SPAK (Ste20 Proline-Alanine rich Ki...

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Foilsithe in:Hypertension
Main Authors: Chávez-Canales, María, Zhang, Chong, Soukaseum, Christelle, Moreno, Erika, Pacheco-Alvarez, Diana, Vidal-Petiot, Emmanuelle, Castañeda-Bueno, María, Vázquez, Norma, Rojas-Vega, Lorena, Meermeier, Nicholas P., Rogers, Shaunessy, Jeunemaitre, Xavier, Yang, Chao-Ling, Ellison, David H, Gamba, Gerardo, Hadchouel, Juliette
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832045/
https://ncbi.nlm.nih.gov/pubmed/25113964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04036
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