The WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the NaCl cotransporter via SPAK, an effect antagonized by WNK4

The With No lysine kinases WNK1 and WNK4 are key regulators of blood pressure. Their mutations lead to Familial Hyperkalemic Hypertension (FHHt), associated with an activation of the Na-Cl cotransporter, NCC. Although it is clear that WNK4 mutants activate NCC via SPAK (Ste20 Proline-Alanine rich Ki...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Hypertension
Prif Awduron: Chávez-Canales, María, Zhang, Chong, Soukaseum, Christelle, Moreno, Erika, Pacheco-Alvarez, Diana, Vidal-Petiot, Emmanuelle, Castañeda-Bueno, María, Vázquez, Norma, Rojas-Vega, Lorena, Meermeier, Nicholas P., Rogers, Shaunessy, Jeunemaitre, Xavier, Yang, Chao-Ling, Ellison, David H, Gamba, Gerardo, Hadchouel, Juliette
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832045/
https://ncbi.nlm.nih.gov/pubmed/25113964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04036
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