The WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the NaCl cotransporter via SPAK, an effect antagonized by WNK4

The With No lysine kinases WNK1 and WNK4 are key regulators of blood pressure. Their mutations lead to Familial Hyperkalemic Hypertension (FHHt), associated with an activation of the Na-Cl cotransporter, NCC. Although it is clear that WNK4 mutants activate NCC via SPAK (Ste20 Proline-Alanine rich Ki...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Hypertension
Egile Nagusiak: Chávez-Canales, María, Zhang, Chong, Soukaseum, Christelle, Moreno, Erika, Pacheco-Alvarez, Diana, Vidal-Petiot, Emmanuelle, Castañeda-Bueno, María, Vázquez, Norma, Rojas-Vega, Lorena, Meermeier, Nicholas P., Rogers, Shaunessy, Jeunemaitre, Xavier, Yang, Chao-Ling, Ellison, David H, Gamba, Gerardo, Hadchouel, Juliette
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832045/
https://ncbi.nlm.nih.gov/pubmed/25113964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04036
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