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Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC
Familial hyperkalemic hypertension (FHHt) can be mainly attributed to increased activity of the renal Na(+):Cl(−) cotransporter (NCC), which is caused by altered expression and regulation of the with-no-lysine (K) 1 (WNK1) or WNK4 kinases. The WNK1 gene gives rise to a kidney-specific isoform that l...
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| Опубликовано в: : | Am J Physiol Renal Physiol |
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| Главные авторы: | , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Physiological Society
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6172580/ https://ncbi.nlm.nih.gov/pubmed/29846116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00145.2018 |
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