Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC

Familial hyperkalemic hypertension (FHHt) can be mainly attributed to increased activity of the renal Na(+):Cl(−) cotransporter (NCC), which is caused by altered expression and regulation of the with-no-lysine (K) 1 (WNK1) or WNK4 kinases. The WNK1 gene gives rise to a kidney-specific isoform that l...

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Argaiz, Eduardo R., Chavez-Canales, Maria, Ostrosky-Frid, Mauricio, Rodríguez-Gama, Alejandro, Vázquez, Norma, Gonzalez-Rodriguez, Xochiquetzal, Garcia-Valdes, Jesus, Hadchouel, Juliette, Ellison, David, Gamba, Gerardo
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6172580/
https://ncbi.nlm.nih.gov/pubmed/29846116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00145.2018
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