The Effect of WNK4 on the Na(+)–Cl(−) Cotransporter Is Modulated by Intracellular Chloride

It is widely recognized that the phenotype of familial hyperkalemic hypertension is mainly a consequence of increased activity of the renal Na(+)–Cl(−) cotransporter (NCC) because of altered regulation by with no–lysine–kinase 1 (WNK1) or WNK4. The effect of WNK4 on NCC, however, has been controvers...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Bazúa-Valenti, Silvana, Chávez-Canales, María, Rojas-Vega, Lorena, González-Rodríguez, Xochiquetzal, Vázquez, Norma, Rodríguez-Gama, Alejandro, Argaiz, Eduardo R., Melo, Zesergio, Plata, Consuelo, Ellison, David H., García-Valdés, Jesús, Hadchouel, Juliette, Gamba, Gerardo
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2015
Subjects:
Brief Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4520168/
https://ncbi.nlm.nih.gov/pubmed/25542968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014050470
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