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WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na(+)-Cl(−) cotransporter
Loss of physiological regulation of the renal thiazide-sensitive Na(+)-Cl(−) cotransporter (NCC) by mutant WNK1 or WNK4 results in pseudohypoaldosteronism type II (PHAII) characterized by arterial hypertension and hyperkalemia. WNK4 normally inhibits NCC, but this effect is lost by eliminating WNK4...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Physiological Society
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2576145/ https://ncbi.nlm.nih.gov/pubmed/18701621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90396.2008 |
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