Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

Mutations in the kinase WNK4 cause pseudohypoaldosteronism type II (PHAII), a syndrome featuring hypertension and high serum K(+) levels (hyperkalemia). WNK4 has distinct functional states that regulate the balance between renal salt reabsorption and K(+) secretion by modulating the activities of re...

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Autori principali: San-Cristobal, Pedro, Pacheco-Alvarez, Diana, Richardson, Ciaran, Ring, Aaron M., Vazquez, Norma, Rafiqi, Fatema H., Chari, Divya, Kahle, Kristopher T., Leng, Qiang, Bobadilla, Norma A., Hebert, Steven C., Alessi, Dario R., Lifton, Richard P., Gamba, Gerardo
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647339/
https://ncbi.nlm.nih.gov/pubmed/19240212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813238106
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