Activation of the renal Na(+):Cl(−) cotransporter by angiotensin II is a WNK4-dependent process

Pseudohypoaldosteronism type II is a salt-sensitive form of hypertension with hyperkalemia in humans caused by mutations in the with-no-lysine kinase 4 (WNK4). Several studies have shown that WNK4 modulates the activity of the renal Na(+)Cl(−) cotransporter, NCC. Because the renal consequences of WN...

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Detalhes bibliográficos
Main Authors: Castañeda-Bueno, María, Cervantes-Pérez, Luz Graciela, Vázquez, Norma, Uribe, Norma, Kantesaria, Sheila, Morla, Luciana, Bobadilla, Norma A., Doucet, Alain, Alessi, Dario R., Gamba, Gerardo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356635/
https://ncbi.nlm.nih.gov/pubmed/22550170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200947109
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