Defective regulation of the epithelial Na(+) channel by Nedd4 in Liddle's syndrome

Liddle's syndrome is an inherited form of hypertension linked to mutations in the epithelial Na(+) channel (ENaC). ENaC is composed of three subunits (α, β, γ), each containing a COOH-terminal PY motif (xPPxY). Mutations causing Liddle's syndrome alter or delete the PY motifs of β- or γ-EN...

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Huvudupphovsmän: Abriel, Hugues, Loffing, Johannes, Rebhun, John F., Pratt, J. Howard, Schild, Laurent, Horisberger, Jean-Daniel, Rotin, Daniela, Staub, Olivier
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 1999
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC408130/
https://ncbi.nlm.nih.gov/pubmed/10074483
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