WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

The amiloride-sensitive epithelial sodium channel (ENaC) plays a major role in sodium transport in kidney and other epithelia, and in regulating blood pressure. The channel is composed of three subunits (alphabetagamma) each containing two proline-rich sequences (P1 and P2) at its C-terminus. The P2...

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Bibliographic Details
Published in:EMBO J
Main Authors: Staub, O, Dho, S, Henry, P, Correa, J, Ishikawa, T, McGlade, J, Rotin, D
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1996
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC450167/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8665844/
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