Renal tubular SGK1 deficiency causes impaired K(+) excretion via loss of regulation of NEDD4-2/WNK1 and ENaC

The stimulation of postprandial K(+) clearance involves aldosterone-independent and -dependent mechanisms. In this context, serum- and glucocorticoid-induced kinase (SGK)1, a ubiquitously expressed kinase, is one of the primary aldosterone-induced proteins in the aldosterone-sensitive distal nephron...

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Published in:Am J Physiol Renal Physiol
Main Authors: Al-Qusairi, Lama, Basquin, Denis, Roy, Ankita, Stifanelli, Matteo, Rajaram, Renuga Devi, Debonneville, Anne, Nita, Izabela, Maillard, Marc, Loffing, Johannes, Subramanya, Arohan R., Staub, Olivier
Format: Artigo
Language:Inglês
Published: American Physiological Society 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5005279/
https://ncbi.nlm.nih.gov/pubmed/27009335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00002.2016
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