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WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination
A serine-threonine protein kinase, WNK4, reduces Na(+) reabsorption and K(+) secretion in the distal convoluted tubule by reducing trafficking of the thiazide-sensitive Na-Cl cotransporter to and enhancing renal outer medullary potassium channel retrieval from the apical membrane. Epithelial sodium...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3725674/ https://ncbi.nlm.nih.gov/pubmed/23594824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00652.2012 |
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