WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination

A serine-threonine protein kinase, WNK4, reduces Na(+) reabsorption and K(+) secretion in the distal convoluted tubule by reducing trafficking of the thiazide-sensitive Na-Cl cotransporter to and enhancing renal outer medullary potassium channel retrieval from the apical membrane. Epithelial sodium...

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Main Authors: Yu, Ling, Cai, Hui, Yue, Qian, Alli, Abdel A., Wang, DeXuan, Al-Khalili, Otor, Bao, Hui-Fang, Eaton, Douglas C.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725674/
https://ncbi.nlm.nih.gov/pubmed/23594824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00652.2012
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