The inhibitory effect of G(βγ) and G(β) isoform specificity on ENaC activity

Epithelial Na(+) channel (ENaC) activity, which determines the rate of renal Na(+) reabsorption, can be regulated by G protein-coupled receptors. Regulation of ENaC by Gα-mediated downstream effectors has been studied extensively, but the effect of G(βγ) dimers on ENaC is unclear. A6 cells endogenou...

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Main Authors: Yu, Ling, Al-Khalili, Otor, Duke, Billie Jeanne, Stockand, James D., Eaton, Douglas C., Bao, Hui-Fang
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840225/
https://ncbi.nlm.nih.gov/pubmed/23863469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00009.2013
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