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Biphasic regulation of ENaC by TGF-α and EGF in renal epithelial cells

The epithelial sodium channel (ENaC) is regulated by epidermal growth factor (EGF). We investigate whether ENaC is regulated by another EGF receptor (EGFR) ligand, transforming growth factor-α (TGF-α). We show that chronic (24 h) treatment with TGF-α inhibits ENaC in Xenopus laevis kidney cells 20 t...

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Bibliografiske detaljer
Main Authors: Liu, Lian, Duke, Billie Jeanne, Malik, Bela, Yue, Qiang, Eaton, Douglas C.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692443/
https://ncbi.nlm.nih.gov/pubmed/19297452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90337.2008
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