mTOR Complex-2 Activates ENaC by Phosphorylating SGK1

The serum- and glucocorticoid-induced kinase 1 (SGK1) plays a central role in hormone regulation of epithelial sodium (Na(+)) channel (ENaC)-dependent Na(+) transport in the distal nephron. Phosphorylation within a carboxy-terminal domain, designated the hydrophobic motif (HM), determines the activi...

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Detalhes bibliográficos
Main Authors: Lu, Ming, Wang, Jian, Jones, Kevin T., Ives, Harlan E., Feldman, Morris E., Yao, Li-jun, Shokat, Kevan M., Ashrafi, Kaveh, Pearce, David
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2010
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865740/
https://ncbi.nlm.nih.gov/pubmed/20338997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009111168
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