Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation

per Derkow, Katja, Krüger, Christina, Dembny, Paul, Lehnardt, Seija
Publicat a PLoS One (2015)

The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration

per Rosenberger, Karen, Derkow, Katja, Dembny, Paul, Krüger, Christina, Schott, Eckart, Lehnardt, Seija
Publicat 2014

The Role of Regulatory CD4 T Cells in Maintaining Tolerance in a Mouse Model of Autoimmune Hepatitis

per an Haack, Ira, Derkow, Katja, Riehn, Mathias, Rentinck, Marc-Nicolas, Kühl, Anja A., Lehnardt, Seija, Schott, Eckart
Publicat a PLoS One (2015)

Identification of CNS Injury-Related microRNAs as Novel Toll-Like Receptor 7/8 Signaling Activators by Small RNA Sequencing

per Wallach, Thomas, Wetzel, Max, Dembny, Paul, Staszewski, Ori, Krüger, Christina, Buonfiglioli, Alice, Prinz, Marco, Lehnardt, Seija
Publicat a Cells (2020)

A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS

per Lehnardt, Seija, Schott, Eckart, Trimbuch, Thorsten, Laubisch, Dinah, Krueger, Christina, Wulczyn, Gregory, Nitsch, Robert, Weber, Joerg R.
Publicat a J Neurosci (2008)

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

per Lehnardt, Seija, Massillon, Leon, Follett, Pamela, Jensen, Frances E., Ratan, Rajiv, Rosenberg, Paul A., Volpe, Joseph J., Vartanian, Timothy
Publicat 2003

Glioma associated microglial MMP9 expression is up regulated by TLR2 signalling and sensitive to minocycline

per Hu, Feng, Ku, Min-Chi, Markovic, Darko, Dzaye, Omar Dildar a, Lehnardt, Seija, Synowitz, Michael, Wolf, Susanne A., Kettenmann, Helmut
Publicat a Int J Cancer (2014)

Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway

per Rosenberger, Karen, Dembny, Paul, Derkow, Katja, Engel, Odilo, Krüger, Christina, Wolf, Susanne A, Kettenmann, Helmut, Schott, Eckart, Meisel, Andreas, Lehnardt, Seija
Publicat a Mol Neurodegener (2015)

Distinct expression of the neurotoxic microRNA family let-7 in the cerebrospinal fluid of patients with Alzheimer's disease

per Derkow, Katja, Rössling, Rosa, Schipke, Carola, Krüger, Christina, Bauer, Jakob, Fähling, Michael, Stroux, Andrea, Schott, Eckart, Ruprecht, Klemens, Peters, Oliver, Lehnardt, Seija
Publicat a PLoS One (2018)

The Toll-Like Receptor TLR4 Is Necessary for Lipopolysaccharide-Induced Oligodendrocyte Injury in the CNS

per Lehnardt, Seija, Lachance, Christian, Patrizi, Silvia, Lefebvre, Sharon, Follett, Pamela L., Jensen, Frances E., Rosenberg, Paul A., Volpe, Joseph J., Vartanian, Timothy
Publicat a J Neurosci (2002)

Glioma Stem Cells but Not Bulk Glioma Cells Upregulate IL-6 Secretion in Microglia/Brain Macrophages via Toll-like Receptor 4 Signaling

per a Dzaye, Omar Dildar, Hu, Feng, Derkow, Katja, Haage, Verena, Euskirchen, Philipp, Harms, Christoph, Lehnardt, Seija, Synowitz, Michael, Wolf, Susanne A., Kettenmann, Helmut
Publicat a J Neuropathol Exp Neurol (2016)

Expression of Toll-Like Receptors in the Developing Brain

per Kaul, David, Habbel, Piet, Derkow, Katja, Krüger, Christina, Franzoni, Eleonora, Wulczyn, F. Gregory, Bereswill, Stefan, Nitsch, Robert, Schott, Eckart, Veh, Rüdiger, Naumann, Thomas, Lehnardt, Seija
Publicat 2012

Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury

per Ifuku, Masataka, Hinkelmann, Lukas, Kuhrt, Leonard D., Efe, Ibrahim E., Kumbol, Victor, Buonfiglioli, Alice, Krüger, Christina, Jordan, Philipp, Fulde, Marcus, Noda, Mami, Kettenmann, Helmut, Lehnardt, Seija
Publicat a Acta Neuropathol Commun (2020)

Multiple Sclerosis: Modulation of Toll-Like Receptor (TLR) Expression by Interferon-β Includes Upregulation of TLR7 in Plasmacytoid Dendritic Cells

per Derkow, Katja, Bauer, Jakob M. J., Hecker, Michael, Paap, Brigitte K., Thamilarasan, Madhan, Koczan, Dirk, Schott, Eckart, Deuschle, Katrin, Bellmann-Strobl, Judith, Paul, Friedemann, Zettl, Uwe K., Ruprecht, Klemens, Lehnardt, Seija
Publicat 2013

Synergistic Toll-like Receptor 3/9 Signaling Affects Properties and Impairs Glioma-Promoting Activity of Microglia

per Huang, Yimin, Zhang, Quan, Lubas, Malgorzata, Yuan, Yang, Yalcin, Fatih, Efe, Ibrahim E., Xia, Pengfei, Motta, Edyta, Buonfiglioli, Alice, Lehnardt, Seija, Dzaye, Omar, Flueh, Charlotte, Synowitz, Michael, Hu, Feng, Kettenmann, Helmut
Publicat a J Neurosci (2020)

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion

per Vinnakota, Katyayni, Hu, Feng, Ku, Min-Chi, Georgieva, Petya B., Szulzewsky, Frank, Pohlmann, Andreas, Waiczies, Sonia, Waiczies, Helmar, Niendorf, Thoralf, Lehnardt, Seija, Hanisch, Uwe-Karsten, Synowitz, Michael, Markovic, Darko, Wolf, Susanne A., Glass, Rainer, Kettenmann, Helmut
Publicat 2013

Glioma-derived versican promotes tumor expansion via glioma-associated microglial/macrophages Toll-like receptor 2 signaling

per Hu, Feng, a Dzaye, Omar Dildar, Hahn, Alexander, Yu, Yong, Scavetta, Rick Joey, Dittmar, Gunnar, Kaczmarek, Adrian Kamil, Dunning, Kylie R., Ricciardelli, Carmela, Rinnenthal, Jan L., Heppner, Frank L., Lehnardt, Seija, Synowitz, Michael, Wolf, Susanne A., Kettenmann, Helmut
Publicat a Neuro Oncol (2015)

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

per Dembny, Paul, Newman, Andrew G., Singh, Manvendra, Hinz, Michael, Szczepek, Michal, Krüger, Christina, Adalbert, Robert, Dzaye, Omar, Trimbuch, Thorsten, Wallach, Thomas, Kleinau, Gunnar, Derkow, Katja, Richard, Bernhard C., Schipke, Carola, Scheidereit, Claus, Stachelscheid, Harald, Golenbock, Douglas, Peters, Oliver, Coleman, Michael, Heppner, Frank L., Scheerer, Patrick, Tarabykin, Victor, Ruprecht, Klemens, Izsvák, Zsuzsanna, Mayer, Jens, Lehnardt, Seija
Publicat a JCI Insight (2020)