Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

Although human endogenous retroviruses (HERVs) represent a substantial proportion of the human genome and some HERVs, such as HERV-K(HML-2), are reported to be involved in neurological disorders, little is known about their biological function. We report that RNA from an HERV-K(HML-2) envelope gene...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Dembny, Paul, Newman, Andrew G., Singh, Manvendra, Hinz, Michael, Szczepek, Michal, Krüger, Christina, Adalbert, Robert, Dzaye, Omar, Trimbuch, Thorsten, Wallach, Thomas, Kleinau, Gunnar, Derkow, Katja, Richard, Bernhard C., Schipke, Carola, Scheidereit, Claus, Stachelscheid, Harald, Golenbock, Douglas, Peters, Oliver, Coleman, Michael, Heppner, Frank L., Scheerer, Patrick, Tarabykin, Victor, Ruprecht, Klemens, Izsvák, Zsuzsanna, Mayer, Jens, Lehnardt, Seija
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205273/
https://ncbi.nlm.nih.gov/pubmed/32271161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131093
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