Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

Although human endogenous retroviruses (HERVs) represent a substantial proportion of the human genome and some HERVs, such as HERV-K(HML-2), are reported to be involved in neurological disorders, little is known about their biological function. We report that RNA from an HERV-K(HML-2) envelope gene...

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Vydáno v:JCI Insight
Hlavní autoři: Dembny, Paul, Newman, Andrew G., Singh, Manvendra, Hinz, Michael, Szczepek, Michal, Krüger, Christina, Adalbert, Robert, Dzaye, Omar, Trimbuch, Thorsten, Wallach, Thomas, Kleinau, Gunnar, Derkow, Katja, Richard, Bernhard C., Schipke, Carola, Scheidereit, Claus, Stachelscheid, Harald, Golenbock, Douglas, Peters, Oliver, Coleman, Michael, Heppner, Frank L., Scheerer, Patrick, Tarabykin, Victor, Ruprecht, Klemens, Izsvák, Zsuzsanna, Mayer, Jens, Lehnardt, Seija
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7205273/
https://ncbi.nlm.nih.gov/pubmed/32271161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.131093
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