Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway

BACKGROUND: Toll-like receptors (TLR) constitute a highly conserved class of receptors through which the innate immune system responds to both pathogen- and host-derived factors. Although TLRs are involved in a wide range of central nervous system (CNS) disorders including neurodegenerative diseases...

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Bibliographic Details
Published in:Mol Neurodegener
Main Authors: Rosenberger, Karen, Dembny, Paul, Derkow, Katja, Engel, Odilo, Krüger, Christina, Wolf, Susanne A, Kettenmann, Helmut, Schott, Eckart, Meisel, Andreas, Lehnardt, Seija
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365525/
https://ncbi.nlm.nih.gov/pubmed/25887709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0003-1
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