Multiple Sclerosis: Modulation of Toll-Like Receptor (TLR) Expression by Interferon-β Includes Upregulation of TLR7 in Plasmacytoid Dendritic Cells

Interferon-β is an established treatment for patients with multiple sclerosis (MS) but its mechanisms of action are not well understood. Viral infections are a known trigger of MS relapses. Toll-like receptors (TLRs) are key components of the innate immune system, which sense conserved structures of...

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Main Authors: Derkow, Katja, Bauer, Jakob M. J., Hecker, Michael, Paap, Brigitte K., Thamilarasan, Madhan, Koczan, Dirk, Schott, Eckart, Deuschle, Katrin, Bellmann-Strobl, Judith, Paul, Friedemann, Zettl, Uwe K., Ruprecht, Klemens, Lehnardt, Seija
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741212/
https://ncbi.nlm.nih.gov/pubmed/23950974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070626
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