Glioma Stem Cells but Not Bulk Glioma Cells Upregulate IL-6 Secretion in Microglia/Brain Macrophages via Toll-like Receptor 4 Signaling

Peripheral macrophages and resident microglia constitute the dominant glioma-infiltrating cells. The tumor induces an immunosuppressive and tumor-supportive phenotype in these glioma-associated microglia/brain macrophages (GAMs). A subpopulation of glioma cells acts as glioma stem cells (GSCs). We e...

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Publicado en:J Neuropathol Exp Neurol
Autores principales: a Dzaye, Omar Dildar, Hu, Feng, Derkow, Katja, Haage, Verena, Euskirchen, Philipp, Harms, Christoph, Lehnardt, Seija, Synowitz, Michael, Wolf, Susanne A., Kettenmann, Helmut
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5009477/
https://ncbi.nlm.nih.gov/pubmed/27030742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnen/nlw016
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