Differential Effects of Rapamycin and Dexamethasone in Mouse Models of Established Allergic Asthma

Por Mushaben, Elizabeth M., Brandt, Eric B., Hershey, Gurjit K. Khurana, Le Cras, Timothy D.
Publicado em 2013

Chronic Allergic Inflammation Causes Vascular Remodeling and Pulmonary Hypertension in Bmpr2 Hypomorph and Wild-Type Mice

Por Mushaben, Elizabeth M., Hershey, Gurjit Khurana, Pauciulo, Michael W., Nichols, William C., Le Cras, Timothy D.
Publicado em 2012

Rapamycin Attenuates Airway Hyperreactivity, Goblet Cells, and IgE in Experimental Allergic Asthma

Por Mushaben, Elizabeth M., Kramer, Elizabeth L., Brandt, Eric B., Hershey, Gurjit K. Khurana, Le Cras, Timothy D.
Publicado em 2011

Rapamycin Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis

Por Korfhagen, Thomas R., Le Cras, Timothy D., Davidson, Cynthia R., Schmidt, Stephanie M., Ikegami, Machiko, Whitsett, Jeffrey A., Hardie, William D.
Publicado em 2009

Inhibition of PI3K by PX-866 Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis

Por Le Cras, Timothy D., Korfhagen, Thomas R., Davidson, Cynthia, Schmidt, Stephanie, Fenchel, Matthew, Ikegami, Machiko, Whitsett, Jeffrey A., Hardie, William D.
Publicado em 2010

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

Por Kasahara, Yasunori, Tuder, Rubin M., Taraseviciene-Stewart, Laimute, Le Cras, Timothy D., Abman, Steven, Hirth, Peter K., Waltenberger, Johannes, Voelkel, Norbert F.
Publicado em 2000

GP130-STAT3 Regulates Epithelial Cell Migration and Is Required for Repair of the Bronchiolar Epithelium

Por Kida, Hiroshi, Mucenski, Michael L., Thitoff, Angela R., Le Cras, Timothy D., Park, Kwon-Sik, Ikegami, Machiko, Müller, Werner, Whitsett, Jeffrey A.
Publicado em 2008

Diesel Exhaust Particles Induce Cysteine Oxidation and S-Glutathionylation in House Dust Mite Induced Murine Asthma

Por Lee, Gerald B., Brandt, Eric B., Xiao, Chang, Gibson, Aaron M., Le Cras, Timothy D., Brown, Lou Ann S., Fitzpatrick, Anne M., Khurana Hershey, Gurjit K.
Publicado em 2013

Sox17 is required for normal pulmonary vascular morphogenesis

Por Lange, Alexander W., Haitchi, Hans Michael, LeCras, Timothy D., Sridharan, Anusha, Xu, Yan, Wert, Susan E., James, Jeanne, Udell, Nicholas, Thurner, Philipp J., Whitsett, Jeffrey A.
Publicado no Dev Biol (2014)

Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung disease

Por Kramer, Elizabeth L., Hardie, William D., Mushaben, Elizabeth M., Acciani, Thomas H., Pastura, Patricia A., Korfhagen, Thomas R., Hershey, Gurjit Khurana, Whitsett, Jeffrey A., Le Cras, Timothy D.
Publicado em 2011

Dual Targeting of MEK and PI3K Pathways Attenuates Established and Progressive Pulmonary Fibrosis

Por Madala, Satish K., Edukulla, Ramakrishna, Phatak, Mukta, Schmidt, Stephanie, Davidson, Cynthia, Acciani, Thomas H., Korfhagen, Thomas R., Medvedovic, Mario, LeCras, Timothy D., Wagner, Kimberly, Hardie, William D.
Publicado em 2014

Diesel exhaust particle induction of IL17A contributes to severe asthma

Por Brandt, Eric B., Kovacic, Melinda Butsch, Lee, Gerald B., Gibson, Aaron M., Acciani, Thomas H., Le Cras, Timothy D., Ryan, Patrick H., Budelsky, Alison L., Khurana Hershey, Gurjit K.
Publicado em 2013

Early Growth Response-1 Suppresses Epidermal Growth Factor Receptor–Mediated Airway Hyperresponsiveness and Lung Remodeling in Mice

Por Kramer, Elizabeth L., Mushaben, Elizabeth M., Pastura, Patricia A., Acciani, Thomas H., Deutsch, Gail H., Khurana Hershey, Gurjit K., Korfhagen, Thomas R., Hardie, William D., Whitsett, Jeffrey A., Le Cras, Timothy D.
Publicado em 2009

Genomic Profile of Matrix and Vasculature Remodeling in TGF-α–Induced Pulmonary Fibrosis

Por Hardie, William D., Korfhagen, Thomas R., Sartor, Maureen A., Prestridge, Adrienne, Medvedovic, Mario, Le Cras, Timothy D., Ikegami, Machiko, Wesselkamper, Scott C., Davidson, Cynthia, Dietsch, Maggie, Nichols, William, Whitsett, Jeffrey A., Leikauf, George D.
Publicado em 2007

Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses promoting asthma susceptibility

Por Brandt, Eric B., Biagini Myers, Jocelyn M., Acciani, Thomas H., Ryan, Patrick H., Sivaprasad, Umasundari, Ruff, Brandy, LeMasters, Grace K., Bernstein, David I., Lockey, James, LeCras, Timothy D., Khurana Hershey, Gurjit K.
Publicado no J Allergy Clin Immunol (2015)

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia

Por Fagan, Karen A., Fouty, Brian W., Tyler, Robert C., Morris, Kenneth G., Hepler, Lisa K., Sato, Koichi, LeCras, Timothy D., Abman, Steven H., Weinberger, Howard D., Huang, Paul L., McMurtry, Ivan F., Rodman, David M.
Publicado em 1999

Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma

Por Le Cras, Timothy D., Acciani, Thomas H., Mushaben, Elizabeth M., Kramer, Elizabeth L., Pastura, Patricia A., Hardie, William D., Korfhagen, Thomas R., Sivaprasad, Umasundari, Ericksen, Mark, Gibson, Aaron M., Holtzman, Michael J., Whitsett, Jeffrey A., Khurana Hershey, Gurjit K.
Publicado em 2011

Pharmacological inhibition of EGFR signaling enhances G-CSF–induced hematopoietic stem cell mobilization

Por Ryan, Marnie A, Nattamai, Kalpana J, Xing, Ellen, Schleimer, David, Daria, Deidre, Sengupta, Amitava, Köhler, Anja, Liu, Wei, Gunzer, Matthias, Jansen, Michael, Ratner, Nancy, Le Cras, Timothy D, Waterstrat, Amanda, Van Zant, Gary, Cancelas, Jose A, Zheng, Yi, Geiger, Hartmut
Publicado no Nat Med (2010)

IL-17A enhances IL-13 activity by enhancing IL-13-induced STAT6 activation

Por Hall, Sara L., Baker, Theresa, Lajoie, Stephane, Richgels, Phoebe K., Yang, Yanfen, McAlees, Jaclyn W., van Lier, Adelaide, Wills-Karp, Marsha, Sivaprasad, Umasundari, Acciani, Thomas H., LeCras, Timothy D., Myers, Jocelyn Biagini, Kovacic, Melinda Butsch, Lewkowich, Ian P.
Publicado no J Allergy Clin Immunol (2016)

A non-redundant role for mouse Serpinb3a in the induction of mucus production in asthma

Por Sivaprasad, Umasundari, Askew, David J., Ericksen, Mark B., Gibson, Aaron M., Stier, Matthew T., Brandt, Eric, Bass, Stacey A., Daines, Michael O., Chakir, Jamila, Stringer, Keith F., Wert, Susan E., Whitsett, Jeffrey A., Le Cras, Timothy D., Wills-Karp, Marsha, Silverman, Gary A., Khurana Hershey, Gurjit K.
Publicado em 2010