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Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma

Increases in the epidermal growth factor receptor (EGFR) have been associated with the severity of airway thickening in chronic asthmatic subjects, and EGFR signaling is induced by asthma-related cytokines and inflammation. The goal of this study was to determine the role of EGFR signaling in a chro...

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Detalhes bibliográficos
Main Authors: Le Cras, Timothy D., Acciani, Thomas H., Mushaben, Elizabeth M., Kramer, Elizabeth L., Pastura, Patricia A., Hardie, William D., Korfhagen, Thomas R., Sivaprasad, Umasundari, Ericksen, Mark, Gibson, Aaron M., Holtzman, Michael J., Whitsett, Jeffrey A., Khurana Hershey, Gurjit K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064289/
https://ncbi.nlm.nih.gov/pubmed/21224214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00346.2010
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