Inhibition of PI3K by PX-866 Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis

Transforming growth factor-α (TGFα) is a ligand for the epidermal growth factor receptor (EGFR). EGFR activation is associated with fibroproliferative processes in human lung disease and animal models of pulmonary fibrosis. EGFR signaling activates several intracellular signaling pathways including...

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Detalhes bibliográficos
Main Authors: Le Cras, Timothy D., Korfhagen, Thomas R., Davidson, Cynthia, Schmidt, Stephanie, Fenchel, Matthew, Ikegami, Machiko, Whitsett, Jeffrey A., Hardie, William D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808075/
https://ncbi.nlm.nih.gov/pubmed/20042669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090123
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