Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma

The phosphatidylinositol-3-kinase (PI3K)/Akt oncogenic pathway is critical in glioblastomas. Loss of PTEN, a negative regulator of the PI3K pathway or activated PI3K/Akt pathway that drive increased proliferation, survival, neovascularization, glycolysis, and invasion is found in 70%–80% of malignan...

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Hlavní autoři: Koul, Dimpy, Shen, Ruijun, Kim, Yong-Wan, Kondo, Yasuko, Lu, Yiling, Bankson, Jim, Ronen, Sabrina M., Kirkpatrick, D. Lynn, Powis, Garth, Yung, W. K. Alfred
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940638/
https://ncbi.nlm.nih.gov/pubmed/20156803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nop058
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