Rapamycin Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis

Transforming growth factor (TGF)-α is a ligand for the epidermal growth factor receptor (EGFR). EGFR activation is associated with fibroproliferative processes in human lung disease and animal models of pulmonary fibrosis. Overexpression of TGF-α in transgenic mice causes progressive and severe pulm...

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Detalhes bibliográficos
Main Authors: Korfhagen, Thomas R., Le Cras, Timothy D., Davidson, Cynthia R., Schmidt, Stephanie M., Ikegami, Machiko, Whitsett, Jeffrey A., Hardie, William D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2009
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778163/
https://ncbi.nlm.nih.gov/pubmed/19244201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0377OC
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