MEK-ERK Pathway Modulation Ameliorates Pulmonary Fibrosis Associated with Epidermal Growth Factor Receptor Activation

Pulmonary fibrosis remains a significant public health burden with no proven therapies. The mitogen-activated protein kinase (MAPK)/MAPK kinase (MEK)/extracellular signal–regulated kinase (ERK) signaling cascade is a major pathway controlling cellular processes associated with fibrogenesis, includin...

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Hlavní autoři: Madala, Satish K., Schmidt, Stephanie, Davidson, Cynthia, Ikegami, Machiko, Wert, Susan, Hardie, William D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326433/
https://ncbi.nlm.nih.gov/pubmed/22021337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2011-0237OC
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