Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis

The p70 ribosomal S6 kinase (p70S6K) is a downstream substrate that is phosphorylated and activated by the mammalian target of rapamycin complex and regulates multiple cellular processes associated with pulmonary fibrogenesis. Two isoforms of the p70S6K have been identified (S6K1 and S6K2), but thei...

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Udgivet i:Am J Respir Cell Mol Biol
Main Authors: Madala, Satish K., Sontake, Vishwaraj, Edukulla, Ramakrishna, Davidson, Cynthia R., Schmidt, Stephanie, Hardie, William D.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248954/
https://ncbi.nlm.nih.gov/pubmed/27438654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0090OC
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