Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression

Interleukin 31 receptor α (IL-31RA) is a novel Type I cytokine receptor that pairs with oncostatin M receptor to mediate IL-31 signaling. Binding of IL-31 to its receptor results in the phosphorylation and activation of STATs, MAPK, and JNK signaling pathways. IL-31 plays a pathogenic role in tissue...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Edukulla, Ramakrishna, Singh, Brijendra, Jegga, Anil G., Sontake, Vishwaraj, Dillon, Stacey R., Madala, Satish K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505597/
https://ncbi.nlm.nih.gov/pubmed/25847241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.622126
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