Inhibition of PI3K by PX-866 Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis

Transforming growth factor-α (TGFα) is a ligand for the epidermal growth factor receptor (EGFR). EGFR activation is associated with fibroproliferative processes in human lung disease and animal models of pulmonary fibrosis. EGFR signaling activates several intracellular signaling pathways including...

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Main Authors: Le Cras, Timothy D., Korfhagen, Thomas R., Davidson, Cynthia, Schmidt, Stephanie, Fenchel, Matthew, Ikegami, Machiko, Whitsett, Jeffrey A., Hardie, William D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Investigative Pathology 2010
Ábhair:
Regular Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808075/
https://ncbi.nlm.nih.gov/pubmed/20042669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090123
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